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Additionally, astrocytes begin to show a significant increase at week 3, with astrogliosis reaching its peak during maximal demyelination occurring around weeks 56 46

Because NAD+ is costly and requires a slow, controlled infusion, its price is higher

10.1016/s0223-5234(02)01424-1 102 GuoY.WangC.CaoJ.GaoJ.ZouX.RenY.et al (2015)

We found that the lymph-borne CD31 antibody rapidly reached the EC plasma membrane in the parenchymal blood vessels in the cortex and paracortex (Figure 1B)